ð€ãã€ç ã®åå . çºçã¡ã«ããºã ã説æããã¢ãã«ãŸãšã.
ãã€ç ã®çºçã¯ãçç©åŠçãå¿ççã瀟äŒçèŠå ãè€éã«çµ¡ã¿åãçµæã§ããã1ã€ã®ã¢ãã«ã ãã§ã¯èª¬æããããªãéšåããã.
åå ãåããã°å¯ŸåŠãããã£ãŠãã€ç ãªãããç°¡åã§ããð
ççåŠ
- ð¡ã¢ãã¢ãã³ä»®èª¬: ã»ãããã³äžè¶³. çéå€å žçè«. è¬æŒ¬ãã , æ¥å ãæµŽã³ãïŒ 1960~
- ð¡HPAç³»é害説: ã³ã«ããŸãŒã«éå°åæ³, å¯è ã¶ã£å£ããŸãã. ã¹ãã¬ã¹ããéãã. 1990~
- ð¡ãã€ç BDNF仮説: BDNFäžè¶³, ãã€ãæ²»ãã«ã¯éåãããããªã. 1990~
- ð¡ãã¯ãã°ãªã¢ä»®èª¬: ãã€ç ã¯è³ã®çç, é£äºç¡ç éåã調ãã, 2000~
ð¡ã¢ãã¢ãã³ä»®èª¬
ã¢ãã¢ãã³ä»®èª¬ãç¥çµäŒéç©è³ªä»®èª¬.
ãã€ç ã¯è³å ã®ã¢ãã¢ãã³ïŒã»ãããã³ããã«ã¢ãã¬ããªã³ãããŒããã³ãªã©ïŒã®äžè¶³ãŸãã¯æ©èœç°åžžã«ãã£ãŠåŒãèµ·ãããããšãã仮説.
- 1960幎代ããæå±ãããå€å
žç仮説.
- ãã€ç ã¯ã»ãããã³äžè¶³
- çµ±å倱調çã¯ããŒããã³éå°
- ç ç©¶è ã¯ãã®ïŒã€ã®ãã«ã¢ã³ãè¬ç©çã«èª¿æŽããã°ãã€ãå æã§ãããšç ç©¶ãã.
ã¢ãã¢ãã³ä»®èª¬ - è³ç§åŠèŸå ž
ãã€ç ã»ãããã³äžè¶³
è³å ã®ðã»ãããã³ãäžè¶³ãããšé¬±ã«ãªããšãã仮説. éžæçã»ãããã³ãšãããã¿ã€ãã®ãåŠæ¹ããã.
æã®ä»®èª¬. å¹ãã£ãœãããšã¯ç¢ºãã ãããªãå¹ãã®ãã¡ã«ããºã ã¯æªã äžæ?
ããã40幎ãããéå»ãã£ãšããã ã£ãããããæè¿ã¯ãããšã¯å¥ã®ä»®èª¬ããããããã. ããèªäœãæªããšããããã§ã¯ãªã, ããã ããå šãŠã§ã¯ãªãããããªèŠå ãããäžã®äžã€. å¥ã®äººã«ã¯å¹æããã£ããããããªã. ãããã«ã¯10å¹Žå¹æãªãã£ãã®ã§ãã®ä»®èª¬ã¯ãããã«ã¯çã§ã¯ãªã.
æªã è¬ãªãæ°åãšåããããã§ãããªã.
éç
- æãã€è¬ã广ãçºæ®ãããŸã§æ°é±éãããããšã
- å šãŠã®æ£è ãã¢ãã¢ãã³ç°åžžãæã€ããã§ã¯ãªãã
<2025-01-23 Thu 07:58>
ãããã®èª²é¡æã¯ãŸãã«ããïŒããã«æ¯ãåããã人çãªã®ã§ãä»ã®ã¢ãã«ãç¥ããããšããã®ã匷çãªãã€ç
ãåŠã³ãããšããåæ©.
ð¡ãã€ç HPAç³»é害説
ãã€ç ã³ã«ããŸãŒã«ä»®èª¬. ã³ã«ããŸãŒã«ä»®èª¬ïŒHPA系仮説ïŒ. ç¥çµçްèé害仮説. ðHPA軞
ã³ã«ããŸãŒã«å€§éçç£ãå¯è ã¶ã£å£ããŸãã.
ã¹ãã¬ã¹ã«ããå¯è ããã³ã«ããŸãŒã«ãšãããã«ã¢ã³ãæ ¢æ§çã«éåžžããå€ãåæ³ããããã®çµæãè³ã®æµ·éЬïŒäž»ã«èšæ¶ã«é¢äžããè³å ã®éšäœïŒã®äœç©ãæžå°ããããç¥çµçްèãæ°ããçããããšãæããããŠããŸããŸãïŒWatanabe Y, 1992. Magarison A.M, 1995ïŒã
ãããŠã海銬ã®äœç©ã®æžå°ãç¥çµçŽ°èæ°çã®æå¶ãããã«HPAç³»ã®æŽ»æ§ãä¿ãæªåŸªç°ãçã¿åºããŸãã
ð¡ãã€ç BDNF仮説
ç¥çµå¯å¡æ§ä»®èª¬ïŒBDNF仮説ïŒ. 2000幎代ã«ç»å Žãã仮説. ðBDNF
ãã€ç ã§ã¯æµ·éЬãäžå¿ã«BDNFã®çºçŸãäœäžããŸãããæãã€è¬ã®æäžã§æµ·éЬã®BDNFã®çºçŸãå¢å ããããšãåç©å®éšã§ããã£ãŠããŸãïŒNibuya M, et al, 1995ïŒã
ãŸã人ã«ãããŠããã€ç æ£è ããã®è¡æž BDNFãäœäžããŠããããšãããã£ãŠããïŒKarege F, et al, 2002. Shimizu E, et al, 2003ïŒãæãã€è¬ãªã©ã®æ²»çã§çç¶ãå埩ãããšãšãã«è¡æž BDNFæ¿åºŠãå¢å ããããšãåãã£ãŠããŠããŸã(Yoshimura R, et al, 2007)
ð¬BDNFãã³ã«ããŸãŒã«ã®æ»æãããã¥ãŒãã³ãå®ã
ð¡HPAç³»é害説ãšBDNFã®é¢ä¿æ§ã«ã€ããŠ.
BDNFã¯æ ¢æ§ã¹ãã¬ã¹ãšé©å¿åã®ç¶±åŒãããŒãã®ãããªãã®.
ðåŠç¿æ§ç¡åæã®ç ç©¶ã§ã¯ãéããããšã諊ããããŠã¹ã¯ãã€ã«ãªã. ããããBDNFãæ³šå°ããããŠã¹ã¯éããããšãã.
ðè³ãéããã«ã¯éåãããªã(SAPRK)! - ãžã§ã³ã»ã¬ã€ãã£(2009)ãã.
察ç
éå.
<2025-01-23 Thu 08:27>
éåã§ãã€ã¯å
æã§ããïŒãšããåžæ. ç¥çµå¯å¡æ§ãäœäžãããšãã€ã«ãªãããã€ãªãããšèšæ¶ååäžããããŠããã¯éåã§ãããããšSparkãã.
ð¡ãã€ç ãã¯ãã°ãªã¢ä»®èª¬
ç¥çµçç仮説. ããŒããã³ãã»ãããã³ã«ä»£ããæ°ãã仮説.
ã¹ãã¬ã¹ã«ããð§ ãã¯ãã°ãªã¢ããIL-1β, IL-6, TNF-αãªã©ã®ççæ§ðãµã€ãã«ã€ã³ãããªãŒã©ãžã«ã«=ðšæŽ»æ§é žçŽ ãåæ³ãããè³å ãççãèµ·ããããã€ç ãçºçãããšãã説.
ççã¹ãã¬ã¹/瀟äŒã¹ãã¬ã¹/å¿çã¹ãã¬ã¹ -> ã¹ãã¬ã¹åå¿ã§è³ãçç -> æãã€çç¶.
- ç¡ç äžè¶³
- ð¡ç€ŸäŒçæåã¹ãã¬ã¹åå¿
- éã蟌ããããããŠã¹ã¯ãã¯ãã°ãªã¢æŽ»æ§å
- ããããããããŠã¹ã¯ãã¯ãã°ãªã¢æŽ»æ§å
ããããä¿¡ããŠããã®ãã³ã¬. ãããã£ãŠéåãç¡ç ãéèãé£ã¹ããšæ¹åãã. ã¯ããã«ã¿ãã®ã¯ðšãã¬ãªããã®æ¬ã ã£ãããª?
ð¡æ ¢æ§ã¹ãã¬ã¹ã¢ãã«/VEGF
VEGFäœäž -> ççä¿é².
æç¶çã«ã¹ãã¬ã¹ã«ããããããšãè¡ç®¡å ç®å¢æ®å åïŒVEGFïŒvascular endothelial growth factorïŒãšããã¿ã³ãã¯è³ªãè³å ãšäœå ã§å¢å ããè³ãšè¡æ¶²ãšã®å¢çã«ããè¡ç®¡å ç®çްèã®ããªã¢æ§é ïŒè¡æ¶²äžã®ç©è³ªãè³å ã«äŸµå ¥ããã®ãé²ãæ§é ïŒã®å€åãçãã.
ð¡ãã€ç ç¡ç äžè¶³èª¬
ããããç¡ç ã«ã€ããŠã®ã¡ã«ããºã ãããã£ãŠããªã. ããã, ãã€ãšç¡ç äžè¶³ã¯çµ±èšçãªåŒ·ãçžé¢ãããããã.
- ðŠãã€ç ã®ç¡ç ãã¿ãŒã³ã¯æ·±ãç¡ç ãæ¥µç«¯ã«æžãã¬ã ç¡ç ã1æéååã«çŸãã
- ð¬ç¡ç æéãšã¡ã¿ããã¡ã³ã¿ã«çŸæ£ãèªç¥æ§ã¯éåžžã«åŒ·ãå»åŠçãšããã³ã¹ããã
ð¡ãã¯ãã°ãªã¢ãç¡æèçæ¬²åãã¿ããã¹ãåžã£ãŠãã仮説 - å è€éåŒ
è³ç§åŠãšç²Ÿç¥ç§åŠãè³ãšå¿ã®æ©æž¡ãããã¯ãã°ãªã¢æŽ»æ§å. ãã¯ãã°ãªã¢ã®æŽ»æ§åããç¡æèçãªè¡åã®éµ. ããã¯å è€éåŒã®ä»®èª¬.
- ãã¯ãã°ãªã¢ã®æŽ»æ§åããç¡æèçãªãã€ãº(é念)ãçºçããããããè¡åå€å®¹ããã.
- æ»ã®æ¬²åã®æ£äœããã¯ãã°ãªã¢æŽ»æ§å.
- ãã¯ãã°ãªã¢æŽ»æ§åãšãèªæ®ºãèªè²¬ãã¡ã©ã³ã³ãªãŒã®çžé¢.
- çã®æ¬²åã®é¢ãã£ãŠãããïŒ
- ãªããªãã°ããã¯ãã°ãªã¢æŽ»æ§åã¯æªããã®ã ãã§ã¯ãªã.
- NGF, BDNF -> ãšãã¹. ã€ãªãããã¬ãžãªãšã³ã¹ãå¹³å.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3580984/
ð¬åççäœçšã®é£äºã¯åãã€å€ã«å¹æµãã
- ä»é±ã®å°ãã¿ïŒãã€ç ã®åå ã¯ãè³ããããªããŠãççããSNSããå¹»èŠãã匷ãããã³ãŒã«ãã¹ã€ãã³ã°ã¯è³ã«è¯ãã®ãïŒ | ãã¬ãªãªç·
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9736199/
å¿çç
- ðèªç¥ã¢ãã«: ã¢ãŒãã³ããã°ã®èªç¥è¡åçæ³.
ð¬ãã€ç æ£è ã¯ã»ãªãšã³ã¹ãããã¯ãŒã¯ãæ®éã®äººã®2å
è³ãåŠå®çãªæèãèšæ¶ãææ ãšãã£ãå çãªæãããã«åŒ·ãå調ããå€éšãžã®æ³šæãåãããããããããæèãåãé¢ãããšãé£ãããªã£ãŠãã.
ãã€ç ã®äººã ãšããã®ã¯ãªãã©ããã€ç ãç¹°ãè¿ããšããæå³. ç©çãµã€ãº2åïŒ
- Scientists find brain network is doubled in size in depressed people, 2024幎.
- ãã€ç æ£è ã¯ãããè³ã®ç¥çµåè·¯ãã2åã®å€§ããããææ°ç ç©¶ | Forbes JAPAN å ¬åŒãµã€ãïŒãã©ãŒãã¹ ãžã£ãã³ïŒ
倧ãããšã¯ã©ãããããšã ãã. ãµã€ãºïŒãã€ç ã¯DNNã®æŽ»æ§åã§èª¬æãããããšãå€ãã£ãã®ã§ãSNã®ãµã€ãºå¢å ã«ããDNMæ©èœäžå šãšããè«ç¹ã¯æ°ãã. ãã ãåãæ¿ãæ©èœãäžèª¿ã«ãã£ãŠãã¬ãã£ãã«åã£ãDMN掻æ§åãšããçå±ãªãã°çŽåŸ.
ð§ ãµãªãšã³ã¹ãããã¯ãŒã¯(SN)
ð¡ãã€ç éºäŒçèŠå 仮説
ðæ§æ Œã®ååã¯éºäŒã§æ±ºãŸã. ããããæ§æ Œãç æ°ãšèšºæããŠæ²»çãããšã¯ã©ãããããšãªã®ã ããã?
- ð®ãã€ç éºäŒä»®èª¬ãšãªã¢ãã¬ã€ã¶ã«
- ð¡ç¥çµççåŸåã¯ææ¡äœã®éºäŒåã¬ãã«ã®å€§ããã§å 倩çã«æ±ºãŸã
ð®ãã€ç éºäŒä»®èª¬ãšãªã¢ãã¬ã€ã¶ã«
èŠçŽãããš,
- ãã€ç ã¯éºäŒçèŠå ã匷ã. ð¡ãã€ç å 倩çéºäŒä»®èª¬
- ðææ¡äœã®äœã次第ã§ãã¬ãã£ãã«åå¿ãããã人ãšãã«ãã人ããã.
- ææ ãã®ãã®ãææ¡äœãã€ãã, ãããå¶åŸ¡ããã®ãåé åé .
- ææ¡äœãšåé åé ã®ç¹ããã¯ðãªã¢ãã¬ã¶ã«ãšãããã¬ãŒãã³ã°ã§åŒ·åã§ãã.
ãªã¢ãã¬ã€ã¶ã«ãšãããããðèªç¥è¡åçæ³ãšãã®æŽŸçã¯ãªã«ããã£ãŠãã ããã广ã¯ãã.
ref. ð¡ç¥çµççåŸåã¯ææ¡äœã®éºäŒåã¬ãã«ã®å€§ããã§å 倩çã«æ±ºãŸã
é²åè«çã¢ãã«
æè¿è©±é¡ã®é²åçç©åŠ, ðé²åå¿çåŠãã. ãã€ã®åœ¹å²ãšã¯ïŒ
ð¡ç€ŸäŒçåŒãããã説
ãã€ç¶æ ã¯å±éºãªç¶æ³ã§ãšãã«ã®ãŒãç¯çŽããç¡é§ãªãªã¹ã¯ãé¿ããããã®é©å¿çæŠç¥ã
ð¡åé¡è§£æ±ºèª¬
ãã€ç çæèã¯è€éãªåé¡ã«éäžãã解決ãå³ãããã®ææ®µã
ð¡ãã€ç ã©ã³ã¯çè«
ã©ã³ã¯ãšã¯çŸ€ãã®äžã§ã®é äœãªã©ç€ŸäŒçå°äœ. ãã€ç¶æ ã¯ç€ŸäŒçå°äœã倱ã£ããã®ã®ããã奪ãè¿ãå¯èœæ§ããªãå Žåã«çããé²åŸ¡åå¿. ðé²è¡æ¬èœ.
ãªãã¬ã¶ã«ã®ç ç©¶ã§, 矀ãã®äžã§é äœã®é«ããªã¹ã¯ã»ãããã³æ¿åºŠãé«ããé äœã®äœããªã¹ã¯ã»ãããã³æ¿åºŠãäœãããšãåãã£ã. é äœã®é«ãåäœã»ã©ç²Ÿç¥ç¶æ ãå®å®ããŠãã. é«ãå°äœãã倱èããŠããŸã£ããªã¹ã¯, ã»ãããã³æ¿åºŠãæ¥æ¿ã«äœäžããããšã確èªããã.
èªèº«ãæè ãšãªã£ããšã, åã¡ç®ã®ãªãçžæã«å¯ŸããŠéäºå¿ïŒéäºããææ¬²ïŒã倱ãããšãªãæŠãç¶ããŠããŸããš, èªèº«ãæ»ãã§ããŸã, ãããã¯æªæãããŠ, ãã®åŸã®ç¹æ®ã«ãã€ãã¹ã®åœ±é¿ãçããå¯èœæ§ããã. ãã£ãã®ããšéäºã¯åããããŠäœãå°äœãçãããŠåãå ¥ããã»ãã, èªèº«ã®çåãä»åŸã®ç¹æ®ã®å¯èœæ§ãç¶æããããã§ã¯, ãŸã ãããŸããªéžæ.
æè ãèªèº«ã®æåãçŽ çŽã«èªããŠåãå ¥ããå Žåã«ã¯ãã€ç¶æ ã¯æ¶ãã.
ããªãã¡, ðã¢ã¯ã»ãã¿ã³ã¹.
ðãã€ã¯åã¡ç®ã®ãªãçžæãžã®éäºæ¬èœã®åŒ·å¶ã¹ããã
ð¡ãã€ç ã©ã³ã¯çè«ãã. ðã¢ã¯ã»ãã¿ã³ã¹ãæå¹.
瀟äŒçéå±€ã®èª¿æŽ. æãã€çãªè¡åã¯, åäœãèªåã瀟äŒçãªç«¶äºã«è² ããŠãããšæãããšãã«åŒãéã«ãªã, ãã®çµæ, åäœãæ°ããªå¯Ÿç«ãåé¿ããããã«ä¿ããããããŸãã.